Neomycin B Sulfate – Properties, Applications, and Bioactivity
Properties:
Melting point: >160?°C (decomposition)
Storage conditions: Hygroscopic; store at -20?°C under inert atmosphere
Solubility: Easily soluble in water; very slightly soluble in alcohol; practically insoluble in acetone
Physical form: Solid
Color: White to off-white
Water solubility: 250?mg/mL (275.06?mM; ultrasonic assistance may be required)
Stability: Hygroscopic
InChIKey: OIXVKQDWLFHVGR-UMGQGINYNA-N
CAS Number: 4146-30-9
Applications:
Neomycin B sulfate has a broad antibacterial spectrum, showing potent bactericidal activity against both Gram-negative and Gram-positive bacteria. It is widely used in pharmaceutical and veterinary applications.
Bioactivity:
Neomycin B sulfate (also known as Framycetin sulfate) is an aminoglycoside antibiotic.
It acts as an effective RNase P cleavage activity inhibitor with a Ki of 35?μM, competing for specific divalent metal ion binding sites in RNase P RNA.
It inhibits the hammerhead ribozyme with a Ki of 13.5?μM.
It serves as a 5″-azido neomycin B precursor, binding to Drosha sites within miR-525, and may be applied in conditions such as hepatic encephalopathy and enteropathogenic E. coli infections.
Neomycin B sulfate combines strong antibacterial activity with specialized molecular interactions, making it valuable both clinically and for research applications.
